Pfizer Oral Weight Loss Drug. What It Is, How Does It Work, And Benefits.

Key Takeaways

Pfizer Oral weight loss drug is quite popular right now. The Pharma giant has developed Danuglipron a weight loss drug.

Are you tired of struggling with weight loss? If that’s a yes, you need to stay with us until the end to know about the exciting news that can do the job for you. The Pharma giant Pfizer has recently introduced a Revolutionary oral weight loss drug that can potentially transform our perspective towards weight management and how we typically approach it.

In this article, we will take a deep dive into the existing Research and everything that is known about this innovative solution. 

What Is Pfizer Oral Weight Loss Drug?

Pfizer, the pharma giant, has developed an oral weight loss drug called danuglipron. It is a medicine you can consume orally to help you lose weight.

In clinical trials, Danuglipron has shown promising results, but it is equally important to remember that this particular drug belongs to glucagon-like peptide-1 agonists. One of the biggest reasons it is a sensation is that you don’t need injections; you can simply swallow it. 

Also, besides helping with weight loss, danuglipron helps manage Type 2 diabetes by improving insulin release and lowering blood sugar levels.

Outcomes Of The Clinical Trials

If we are talking about different weight loss medications and their comparative effectiveness, it becomes necessary also to consider what the outcomes of existing clinical trials convey.

Let’s take a closer look at how Pfizer’s danuglipron stacks up against Ozempic and Wegovy by Novo Nordisk.

In the clinical trials conducted on Ozempic, adults who received a once-a-week injection of 1 milligram experienced an average weight loss of around 9.9 pounds over a period of 30 weeks. Originally intended for diabetes treatment, Ozempic has gained attention for its off-label use in weight loss.

On the other hand, Wegovy, specifically approved for chronic weight management, underwent a phase 3 clinical trial.1Trusted Source✅ | PubMed | Trusted Data From The National Library Of Medicine (Government Authority) Go To SourceAgain, the results were quite remarkable, showing that adults receiving a weekly injection of 2.4 milligrams of Wegovy lost an average of approximately 33 pounds over a span of 68 weeks.


Now, let’s turn our attention to Pfizer’s danuglipron. In the phase 2 clinical trial, Pfizer evaluated the effects of this oral weight loss drug. Although the trial did not directly compare danuglipron with Ozempic or other weight loss medications, it yielded promising results. 

The study revealed a significant reduction in body weight among patients who took either the 120-milligram or 80-milligram versions of danuglipron for 16 weeks. On average, individuals receiving the 120-milligram dosage lost about 10 pounds during the study period.

These findings suggest that Pfizer’s danuglipron shows potential as an effective weight loss option. While it may not have been directly compared to Ozempic or Wegovy, the clinical trial results indicate that danuglipron could be a viable alternative.

However, it must be remembered that the entire journey of weight loss is not a Universal one and is different for everyone, from person to person. This is a significant reason why how your body reacts to this particular drug may or may not be similar to someone else’s.

How Does The Drug Work?

Ozempic, Wegovy, and danuglipron are weight loss drugs that fall under the category of GLP-1 agonists. It is a hormone produced in the gut responsible for regulating processes vital for maintaining appetite and food intake.

By imitating the actions of GLP-1, these medications can help individuals achieve weight loss goals. So when you take this medication, it activates the GLP-1 receptors in your body. This activation leads to several beneficial effects that contribute to weight loss. 

A Step-By-Step Breakdown:

First and foremost, the GLP-1 agonists start the process by stimulating insulin release from the pancreas to help lower blood sugar levels. This helps significantly when a person has Type 2 diabetes.

Next, they slow down the pace at which your stomach gets empty and food moves to the digestive system. This results in a prolonged feeling of fullness and reduced appetite. By helping individuals feel satisfied for extended periods, these drugs make consuming fewer calories easier and make healthier food choices more accessible.

Apart from this, the GLP-1 agonists also do their activities on the brain’s reward and pleasure centers, which alters how you perceive your food cravings.2Trusted Source✅ | PubMed Central | Trusted Data From The National Library Of Medicine (Government Authority) Go To SourceAs a result, they can help curb the intense cravings and emotional eating patterns that often contribute to weight gain. 

They also regulate the release of a special hormone called glucagon, which works contrary to insulin and helps increase blood sugar levels when they drop too low. By suppressing glucagon release, GLP-1 agonists help maintain stable blood sugar levels, reducing the likelihood of spikes and crashes that can lead to overeating.

This drug may also influence certain sections of your brain that are majorly responsible for appetite control and regulating satiety signals. By influencing these areas, GLP-1 agonists can help reset the body’s natural appetite regulation mechanisms, making it easier for individuals to control their portion sizes and overall food intake.

Caution: Before you decide to use this weight loss drug to make your weight loss journey easier, make sure that you use it per a healthcare professional’s direction and guidance. If required, you can also make it a part of your existing weight loss plan and carry on with your regular balanced diet and physical activities for better results.

While they can be effective tools for weight management, individual results may vary, and lifestyle modifications remain crucial for long-term success.

Advantages of Pfizer’s Oral Drug

Pfizer’s danuglipron offers a distinct advantage as an oral treatment option. Here are a few to name:

1. Convenience of Oral Administration: One significant advantage of Pfizer’s danuglipron is its oral form. Unlike injectable medications, which require frequent injections, danuglipron can be taken orally as a pill. This offers a more convenient and user-friendly option for individuals seeking weight loss solutions.

2. Mimicking Natural Hormone: Danuglipron mimics the effects of GLP-1, which is naturally produced in the gut. GLP-1 plays a crucial role in signaling to the brain when a person feels full after eating. 

By replicating this hormone’s action, danuglipron helps control appetite and reduces cravings, making it easier for individuals to manage their food intake.

3. Dual Benefit for Diabetes Management: Besides promoting weight loss, danuglipron has another advantage—it aids in managing Type 2 diabetes. This is done by encouraging the release of insulin, which helps regulate blood sugar levels in the body.

This dual benefit of weight loss and improved blood sugar control makes danuglipron a valuable option for individuals with weight management and diabetes concerns.

4. Potential Long-Term Usage: Since danuglipron is an oral medication, it may be a preferable choice for individuals who are averse to injections or have difficulty with regular injection schedules. This characteristic opens up possibilities for long-term usage and adherence to the prescribed treatment, which is crucial for achieving sustained weight loss.


Obesity and severe obesity affect many people, and finding effective ways to lose weight is essential. Pfizer’s danuglipron has shown promising results in clinical trials and brings a new option to the weight loss drug market. 

As the current research helps us develop better and, most importantly, safer weight loss solutions, we can hope for powerful treatments to ease the pain one goes through while on their weight loss journey.

  • 1
    Trusted Source✅ | PubMed | Trusted Data From The National Library Of Medicine (Government Authority) Go To Source
  • 2
    Trusted Source✅ | PubMed Central | Trusted Data From The National Library Of Medicine (Government Authority) Go To Source

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