4 Best Peptides For Weight Loss. Benefits And Side Effects.

With obesity on the rise, people constantly seek ways to shed extra pounds and improve their health. After all, cutting away those extra pounds can make a significant good impact on our health and happiness. While still a lot of people rely on exercise and good nutrition to get in shape, there has been a slide inclination toward peptides to have an extra edge. 

In this article, we’ll explore using peptides for weight loss, including the advantages, drawbacks, and the top options available. 

What Are Peptides?

These are mini variants of proteins that are made up of short chains of amino acids, which are basically the building blocks of large proteins. While proteins are made up of more than 50 amino acids, peptides generally consist of only 2-50 amino acids, which makes them much easier for the body to absorb.1Trusted Source✅ | StatPearls | Trusted Data From The National Library Of Medicine (Government Website) Go To Source

Peptides play a variety of roles within the human body and can be used for different purposes. In fact, some are even used in medications to treat conditions such as diabetes and multiple sclerosis.


Do Peptides Help You Lose Weight?

There are different types of peptides and all have different things to do. That is to keep in mind that except for Semaglutide, no Peptides have been approved by the FDA for weight loss use. Peptides can be taken orally or can be injected directly, too.

Peptides are naturally made by our bodies but some peptides are also made in labs. Lab-made peptides can mimic some of the peptides naturally found in our bodies. Peptides like Semaglutide mimic GLP-1. GLP-1 hormone plays an important role in appetite and digestion. GLP-1 is released in the body after you eat to help lower your blood sugar by triggering insulin release and blocking sugar production. And as a result of this process, you feel full and eat less and end up losing weight.

That’s how Peptides can help you lose weight.

Benefits And Potential Side Effects Of Peptides

Now that we understand the basics of peptides and what they basically do, let’s take a look at the key benefits associated with them. 

Improved athletic performance: Certain peptides, like creatine peptides, work by increasing the production of ATP (adenosine triphosphate) that provides energy for muscle contractions.2Trusted Source | PubMed Central| Trusted Data From The National Library Of Medicine (Government Website) Go To Source By increasing their production, peptides can help improve muscle strength and endurance which leads to improved athletic performance. 

✅ Better Skin Health: Collagen is a protein that makes up a significant portion of our skin, and collagen peptides are small chains of amino acids that can be easily absorbed by the body. If you consume peptides that contain them, they can significantly help in improving your skin’s hydration, elasticity, and texture. 

✅ Regulating Appetite And Metabolism: Peptides like ghrelin and leptin are known for their properties that help in regulating metabolism and appetite. 

Ghrelin is a hormone that makes you feel hungry, while leptin is a hormone that tells your brain that you are full.3Trusted Source | PubMed Central | Trusted Data From The National Library Of Medicine (Government Website) Go To Source By regulating these hormones, peptides can help reduce appetite and promote weight loss.

While the benefits can certainly help you with weight loss and other related aspects, it is equally necessary to be careful of the potential side effects. Here are a few of these,

  • Gastrointestinal Discomfort: You may experience slight digestive discomforts like bloating, gas, or diarrhea if you are going for oral supplements.
  • Skin Reactions: If you are going for tropical grains and ointments that contain peptides, you might be exposed to certain skin symptoms such as sensitivity, rash, and itching.
  • Potential Drug Interactions: In certain situations, peptides may interact with a given medication like blood thinners, and result in a slight alteration of their effects. In case that happens, it is always recommended to speak to your doctor.
  • Pregnancy And Breastfeeding: Pregnant or breastfeeding individuals should avoid using peptides until they speak to their doctor, as there is limited research on their safety during these times.

Best Peptides For Weight Loss

If you have been considering switching to peptides for your weight loss journey, you will come across numerous options in the market. While there are certainly multiple options, here we have compiled the best ones to make it easier for you.

Let’s take a look at the 4 best peptides you can consider for weight loss, along with their dosage and what they’re best at!

1)- CJC 1295

It is a popular peptide that contains 30 amino acids that are analogous to growth hormones from the pituitary gland. Since it is known to trigger growth hormones, it also stimulates fat metabolism, which then leads to an increase in lean muscle mass and better endurance helping in regulating your sleep cycle better.

Dosage: If we talk about its ideal dosage, it is usually advisable to go for 250-300 mcg daily, which you can cycle for around 60-90 days. 

Ideal for:

  • Enhancing the growth of lean muscle tissue
  • Boosting the breakdown of body fat
  • Possibly enhancing the quality of sleep patterns

2)- Tesamorelin

It is a prominent peptide known for its weight loss effects, which was initially used for the treatment of HIV-related symptoms. Tesamorellin usually targets adipocytes which are responsible for increased fat metabolism. 

One of the best things about this peptide is that it releases growth hormones even within normal homeostatic levels, which can be helpful in avoiding any potential side effects of excessive growth hormones.4Trusted Source | PubMed | Trusted Data From The National Library Of Medicine (Government Website) Go To Source This makes it an ideal solution for anyone who is looking forward to exceeding their natural growth hormone levels. 

Dosage: It is advised to consume up to 2 mg of Tesamorelin and recycle the same process for at least 14 weeks for best results.

Ideal for:

  • Managing lipodystrophy associated with HIV
  • Enhances fat metabolism/breakdown
  • Potentially reduces the likelihood of developing cardiovascular conditions.

3)- 5-Amino-1MQ 

If you are looking for an effective anti-obesity drug with a unique action mechanism, this can be the best possible choice out there. It works by blocking the working mechanism of Nicotinamide N-methyltransferase(NNMT), leading to a faster and more effective cellular metabolism.5Trusted Source | PubMed | Trusted Data From The National Library Of Medicine (Government Website) Go To Source  

Dosage: For the best possible results, it is usually recommended to take one capsule per day for up to 3 months.

Ideal for:

  • Dealing with metabolic issues
  • Reducing weight gained from the diet
  • Using body fat for energy

4)- Semaglutide

It is a new type of injection that helps people who are struggling with weight loss due to health problems like high blood pressure, type 2 diabetes, and high cholesterol. Clinical studies have shown that it is more effective than any other weight loss drug currently available. 

In fact, over half of the participants in a 68-week study lost over 15% of their body weight while taking this medication. Its key ingredient is a hormone called GLP-1 which naturally occurs in our bodies. This hormone helps to lower blood sugar levels and increase insulin production, making it a powerful way to lose weight.

Dosage: It is recommended to take it once a week, which makes it much easier to manage than other weight loss medications.

Ideal for:

  • Improving blood pressure and cholesterol levels.
  • Eliminate cardiovascular risk factors


Although peptides have gained popularity as a potential tool for weight loss, it is essential to keep in mind the potential side effects and consume these mindfully. So far, we have discussed the best options available in the market, which you can go for. 

Nevertheless, it is always advisable to consult with your doctor before starting any peptide therapy to ensure safety and effectiveness. Always remember that these and other weight loss supplements may help you shed those extra pounds, but they should never be taken as a substitute for a healthy lifestyle.


Do Peptides Help You Lose Weight?

Yes, Some Peptides Like Semaglutide Have Been Approved By FDA For Weight Loss. Semaglutide Works By Mimicing GLP-1 Hormone Of The Body That Helps In Lowering Blood Sugar levels And Results In Unintentional Weight Loss.

Which Peptides Is Best For Weight Loss?

Currently, Only Semaglutide Has Been Approved By FDA For Weight Loss.

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    Trusted Source✅ | StatPearls | Trusted Data From The National Library Of Medicine (Government Website) Go To Source
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    Trusted Source | PubMed Central| Trusted Data From The National Library Of Medicine (Government Website) Go To Source
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    Trusted Source | PubMed Central | Trusted Data From The National Library Of Medicine (Government Website) Go To Source
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    Trusted Source | PubMed | Trusted Data From The National Library Of Medicine (Government Website) Go To Source
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    Trusted Source | PubMed | Trusted Data From The National Library Of Medicine (Government Website) Go To Source

About The Author

Hey, There! I am Carol. A little shy and an enthusiastic person. Loves to read and write. Healthcare is my favorite subject. I want to educate more and more women about their mental and physical health. Trying to do the same through my medical writing work.

This Article Is Written By WMDR Team. Our Vision Is To Create A Community Where A Woman Can Get Access To All The Free Resources To Help Her In Her Health, Mental Wellness, And In her Personal Relationships.

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